Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase

Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase

Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.

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Veröffentlicht in:Nucleic Acids Symposium Series 2003-09, Vol.3 (1), p.5-6
Hauptverfasser: Kitade, Yukio, Kojima, Hiroharu, Zulfiqur, Fazila, Yabe, Saori, Yamagiwa, Daisuke, Ito, Yasutomo, Nakanishi, Masayuki, Ueno, Yoshihito, Kim, Hye-Sook, Wataya, Yusuke
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Sprache:eng
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Zusammenfassung:Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/3.1.5