Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease
Abstract Objective To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD). Methods Case-control study including 50 patients with CKD and 20 healthy volunteers. Results SAM level and SAM/SAH ratio in urine were significant...
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| Veröffentlicht in: | Laboratory medicine 2020-01, Vol.51 (1), p.80-85 |
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| creator | Kruglova, Maria Petrovna Grachev, Sergej Vital’evich Bulgakova, Polina Olegovna Ivanov, Alexander Vladimirovich Virus, Edward Danielevich Nikiforova, Ksenya Alexandrovna Fedoseev, Anatolij Nikolaevich Savina, Galina Dmitrievna Kubatiev, Aslan Amirkhanovich |
| description | Abstract
Objective
To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).
Methods
Case-control study including 50 patients with CKD and 20 healthy volunteers.
Results
SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P |
| doi_str_mv | 10.1093/labmed/lmz035 |
| format | Article |
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Objective
To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).
Methods
Case-control study including 50 patients with CKD and 20 healthy volunteers.
Results
SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01).
Conclusion
CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmz035</identifier><identifier>PMID: 31247080</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Chronic kidney failure ; Homocysteine ; Kidney diseases ; Medical research ; Medicine, Experimental ; S-adenosylmethionine ; Type 2 diabetes ; Urine</subject><ispartof>Laboratory medicine, 2020-01, Vol.51 (1), p.80-85</ispartof><rights>American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2019</rights><rights>American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><rights>American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-39a74d1e7c13eec05d8a16c49b7e9ef4aa652604d808b3872d3c8456fee69beb3</citedby><cites>FETCH-LOGICAL-c390t-39a74d1e7c13eec05d8a16c49b7e9ef4aa652604d808b3872d3c8456fee69beb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31247080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kruglova, Maria Petrovna</creatorcontrib><creatorcontrib>Grachev, Sergej Vital’evich</creatorcontrib><creatorcontrib>Bulgakova, Polina Olegovna</creatorcontrib><creatorcontrib>Ivanov, Alexander Vladimirovich</creatorcontrib><creatorcontrib>Virus, Edward Danielevich</creatorcontrib><creatorcontrib>Nikiforova, Ksenya Alexandrovna</creatorcontrib><creatorcontrib>Fedoseev, Anatolij Nikolaevich</creatorcontrib><creatorcontrib>Savina, Galina Dmitrievna</creatorcontrib><creatorcontrib>Kubatiev, Aslan Amirkhanovich</creatorcontrib><title>Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease</title><title>Laboratory medicine</title><addtitle>Lab Med</addtitle><description>Abstract
Objective
To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).
Methods
Case-control study including 50 patients with CKD and 20 healthy volunteers.
Results
SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01).
Conclusion
CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.</description><subject>Chronic kidney failure</subject><subject>Homocysteine</subject><subject>Kidney diseases</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>S-adenosylmethionine</subject><subject>Type 2 diabetes</subject><subject>Urine</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkdFrFDEQxoMo9lp99FUCvvRle9kkm2wej1OreCCofQ7ZZNZL2U3OZJdy_evNeS21RZB5GObjNx8zfAi9qclFTRRbDqYbwS2H8Zaw5hla1IqzSkpGnqMFIURWDaHyBJ3mfF1GrgR9iU5YTbkkLVkgv4k3-HtlHISY98MI09bH4AMs_1K3cYx2nycoOv5mJh-xD_gqHUaf8SrnaL2ZwOEbP23xepuKhcVfvAuwx-99BpPhFXrRmyHD67t-hq4-fvix_lRtvl5-Xq82lWWKTBVTRnJXg7Q1A7Ckca2pheWqk6Cg58aIhgrCXUvajrWSOmZb3ogeQKgOOnaGzo--uxR_zZAnPfpsYRhMgDhnTWlDBC8OoqDvnqDXcU6hXKcLRBVjRLYP1E8zgPahj1My9mCqV0JJSYmgvFAX_6BKORi9jQF6X_RHC9VxwaaYc4Je75IfTdrrmuhDtPoYrT5GW_i3d8fOf-R7-j7Lh8fjvPuP12_XyK3Q</recordid><startdate>20200102</startdate><enddate>20200102</enddate><creator>Kruglova, Maria Petrovna</creator><creator>Grachev, Sergej Vital’evich</creator><creator>Bulgakova, Polina Olegovna</creator><creator>Ivanov, Alexander Vladimirovich</creator><creator>Virus, Edward Danielevich</creator><creator>Nikiforova, Ksenya Alexandrovna</creator><creator>Fedoseev, Anatolij Nikolaevich</creator><creator>Savina, Galina Dmitrievna</creator><creator>Kubatiev, Aslan Amirkhanovich</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200102</creationdate><title>Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease</title><author>Kruglova, Maria Petrovna ; Grachev, Sergej Vital’evich ; Bulgakova, Polina Olegovna ; Ivanov, Alexander Vladimirovich ; Virus, Edward Danielevich ; Nikiforova, Ksenya Alexandrovna ; Fedoseev, Anatolij Nikolaevich ; Savina, Galina Dmitrievna ; Kubatiev, Aslan Amirkhanovich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-39a74d1e7c13eec05d8a16c49b7e9ef4aa652604d808b3872d3c8456fee69beb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chronic kidney failure</topic><topic>Homocysteine</topic><topic>Kidney diseases</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>S-adenosylmethionine</topic><topic>Type 2 diabetes</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kruglova, Maria Petrovna</creatorcontrib><creatorcontrib>Grachev, Sergej Vital’evich</creatorcontrib><creatorcontrib>Bulgakova, Polina Olegovna</creatorcontrib><creatorcontrib>Ivanov, Alexander Vladimirovich</creatorcontrib><creatorcontrib>Virus, Edward Danielevich</creatorcontrib><creatorcontrib>Nikiforova, Ksenya Alexandrovna</creatorcontrib><creatorcontrib>Fedoseev, Anatolij Nikolaevich</creatorcontrib><creatorcontrib>Savina, Galina Dmitrievna</creatorcontrib><creatorcontrib>Kubatiev, Aslan Amirkhanovich</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kruglova, Maria Petrovna</au><au>Grachev, Sergej Vital’evich</au><au>Bulgakova, Polina Olegovna</au><au>Ivanov, Alexander Vladimirovich</au><au>Virus, Edward Danielevich</au><au>Nikiforova, Ksenya Alexandrovna</au><au>Fedoseev, Anatolij Nikolaevich</au><au>Savina, Galina Dmitrievna</au><au>Kubatiev, Aslan Amirkhanovich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease</atitle><jtitle>Laboratory medicine</jtitle><addtitle>Lab Med</addtitle><date>2020-01-02</date><risdate>2020</risdate><volume>51</volume><issue>1</issue><spage>80</spage><epage>85</epage><pages>80-85</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract>Abstract
Objective
To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).
Methods
Case-control study including 50 patients with CKD and 20 healthy volunteers.
Results
SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01).
Conclusion
CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31247080</pmid><doi>10.1093/labmed/lmz035</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Laboratory medicine, 2020-01, Vol.51 (1), p.80-85 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1093_labmed_lmz035 |
| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Chronic kidney failure Homocysteine Kidney diseases Medical research Medicine, Experimental S-adenosylmethionine Type 2 diabetes Urine |
| title | Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease |
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