Declining Immune Function in Children and Adolescents With Hemophilia and HIV Infection : Effects on Neuropsychological Performance

Objective : To determine whether declines in immune functioning are associated with changes in neuropsychological performance in children and adolescents with hemophilia who are infected with the human immunodeficiency virus (HIV). Methods : Participants were 333 males with hemophilia, ages 6-19 yea...

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Veröffentlicht in:Journal of pediatric psychology 2000-07, Vol.25 (5), p.309-322
Hauptverfasser: Loveland, Katherine A., Stehbens, James A., Mahoney, Elizabeth M., Sirois, Patricia A., Nichols, Sharon, Bordeaux, Janice D., Watkins, John M., Amodei, Nancy, Hill, Suzanne D., Donfield, Sharyne
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Sprache:eng
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Zusammenfassung:Objective : To determine whether declines in immune functioning are associated with changes in neuropsychological performance in children and adolescents with hemophilia who are infected with the human immunodeficiency virus (HIV). Methods : Participants were 333 males with hemophilia, ages 6-19 years at entry. A baseline and four annual neuropsychological evaluations were given. A longitudinal growth curves analysis of data was performed to detect changes associated with declining immune function. The cohort was stratified into four groups : (1) HIV- (n = 126) ; (2) HIV+, average of first two and last two CD4 counts ≥200, (n = 106 ; High CD4 group) ; (3) HIV+, average first two counts ≥200, average last two counts
ISSN:0146-8693
1465-735X
1465-735X
DOI:10.1093/jpepsy/25.5.309