Induction of Stomach Cancer in Rats and Mice by Halogenated Aliphatic Fumigants

Ethylene dibromide and 1,2-dibromo-3-chloropropane (DBCP) were administered to Osborne-Mendel rats and (C57BL × C3H)F1 mice via chronic oral intubation 5 times per week at experimentally predetermined maximally tolerated doses and at half those doses. As early as 10 weeks after initiation of treatme...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1973-12, Vol.51 (6), p.1993-1995
Hauptverfasser:	Olson, William A., Habermann, Robert T., Weisburger, Elizabeth K., Ward, Jerrold M., Weisburger, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Animals Carcinogens Carcinoma, Squamous Cell - chemically induced Ethane - toxicity Female Hydrocarbons, Brominated - toxicity Hydrocarbons, Halogenated - toxicity Insecticides - toxicity Male Mammary Neoplasms, Experimental - chemically induced Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred Strains Neoplasms, Experimental - chemically induced Propane - toxicity Rats Stomach Neoplasms - chemically induced
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Beschreibung
Zusammenfassung:	Ethylene dibromide and 1,2-dibromo-3-chloropropane (DBCP) were administered to Osborne-Mendel rats and (C57BL × C3H)F1 mice via chronic oral intubation 5 times per week at experimentally predetermined maximally tolerated doses and at half those doses. As early as 10 weeks after initiation of treatment, both compounds induced a high incidence of squamous cell carcinomas of the stomach in both species. In addition, DBCP induced mammary adenocarcinomas in the female rats. Possible environmental hazards of these compounds are discussed.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/51.6.1993