Dietary Silymarin Supplementation Alleviates Zearalenone-Induced Hepatotoxicity and Reproductive Toxicity in Rats

Zearalenone (ZEN) can cause serious defects in development and reproduction in humans and animals. Silymarin shows antioxidant and estrogenic effects. This study was conducted to determine if silymarin can antagonize ZEN-induced hepatic and reproductive toxicities. Thirty-five 21-d-old female Spragu...

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Veröffentlicht in:	The Journal of nutrition 2018-08, Vol.148 (8), p.1209-1216
Hauptverfasser:	Gao, Xin, Xiao, Zhuo-Hui, Liu, Meng, Zhang, Ni-Ya, Khalil, Mahmoud Mohamed, Gu, Chang-Qin, Qi, De-Sheng, Sun, Lv-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use ATP-Binding Cassette Transporters - metabolism Blood Proteins - metabolism Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Dietary Supplements Estrogen Receptor alpha - blood Female Glutathione Peroxidase - metabolism hepatotoxicity Hormones - blood Hydroxysteroid Dehydrogenases - metabolism Liver - drug effects Liver - enzymology Liver - pathology Malondialdehyde - blood Multidrug Resistance-Associated Proteins - metabolism Ovary - drug effects Ovary - pathology Phytotherapy rats Rats, Sprague-Dawley Reproduction - drug effects reproductive toxicity Ribosomal Protein S6 Kinases, 70-kDa - metabolism Silybum marianum - chemistry silymarin Silymarin - pharmacology Silymarin - therapeutic use Uterus - drug effects Uterus - pathology zearalenone Zearalenone - toxicity
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Zusammenfassung:	Zearalenone (ZEN) can cause serious defects in development and reproduction in humans and animals. Silymarin shows antioxidant and estrogenic effects. This study was conducted to determine if silymarin can antagonize ZEN-induced hepatic and reproductive toxicities. Thirty-five 21-d-old female Sprague-Dawley rats (n = 7/diet) were fed a control diet (Ctrl) or Ctrl plus 20 mg ZEN/kg or Ctrl plus 20 mg ZEN/kg with 100, 200, or 500 mg silymarin/kg for 6 wk. Serum, livers, ovaries, and uterus were collected at week 6 for biochemistry, hormone, and redox status and selected gene and protein assays. The consumption of ZEN decreased (P
ISSN:	0022-3166 1541-6100
DOI:	10.1093/jn/nxy114