The Heat Production and Blood and Urine Constituents After Administration of d-Arginine Monohydrochloride to the Dog

Upon either intravenous or oral administration of arginine monohydrochloride to the dog there is a prompt and long sustained rise in the urea nitrogen of the blood. There is an excretion of unchanged arginine in the urine reaching considerable proportions in the intravenous experiments. Arginine is metabolized somewhat more slowly than glycine. Arginine exhibits a specific dynamic action, which calculated upon the basis of the amount administered, is less than that of glycine but calculated upon the basis of Calories per millimol deaminized is probably slightly higher than that of glycine. Ornithine, if formed, does not appear in the urine in appreciable quantities. No toxic effects of arginine were noted.