Pretreatment of Urine Samples for the Analysis of 11-nor-Δ9-Tetrahydrocannabinol-9-Carboxylic Acid Using Solid-Phase Extraction

Pretreatment of Urine Samples for the Analysis of 11-nor-Δ9-Tetrahydrocannabinol-9-Carboxylic Acid Using Solid-Phase Extraction

An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. The extra...

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Veröffentlicht in:Journal of analytical toxicology 1990-01, Vol.14 (1), p.39-44
Hauptverfasser: Parry, Ritchard C., Nolan, Lydia, Shirey, Robert E., Wachob, George D., Gisch, Daryl J.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Drug addictions
Medical sciences
Toxicology
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Zusammenfassung:An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. The extraction procedure allows quantitation of the drug metabolite by GC/MS, HPLC with UV detection, or GC with flame ionization detection. The extraction procedure was verified with urine samples obtained from marijuana users as well as spiked urine samples.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/14.1.39