A clinical dose-response study of bacampicillin in uncomplicated gonorrhoea

In a double-blind study of dose-response, 883 cases with uncomplicated gonorrhoea were given single oral doses of 400, 800 or 1600 mg bacampicillin, with 1 g probenecid. Eight hundred and 1600 mg were equally effective with negative cultures in 98.2% and 99.7% of the patients, respectively; 400 mg gave negative cultures in 95.2%. The differences between the lowest dose and the two others were statistically significant. In patients with less sensitive strains, the highest dose was superior. It is concluded that a single dose of bacampicillin 800 mg plus probenecid 1 g was effective in uncomplicated gonorrhoea with fully ampicillin-sensitive strains. In patients with gonococci showing reduced sensitivity to anipicillin the best results, 96.3%, were achieved with the double dose of bacampicillin.