Reduced virulence in ciprofloxacin-resistant variants of Pseudomonas aeruginosa strains

Pseudomonas aeruginosa strains resistant to ciprofloxacin were obtained from parental strains by serial transfer through subinhibitory concentrations of the drug. They showed reduced virulence for mice, and also increased sensitivity to aminoglycosides.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antimicrobial chemotherapy 1987-12, Vol.20 (6), p.825-829
Hauptverfasser:	Ravizzola, G., Pirali, F., Paolucci, A., Terlenghi, L., Peroni, L., Colombi, A., Turano, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Animals Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin - pharmacology Drug Resistance, Microbial Female Lethal Dose 50 Male Medical sciences Mice Pharmacology. Drug treatments Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - pathogenicity Species Specificity Virulence
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Beschreibung
Zusammenfassung:	Pseudomonas aeruginosa strains resistant to ciprofloxacin were obtained from parental strains by serial transfer through subinhibitory concentrations of the drug. They showed reduced virulence for mice, and also increased sensitivity to aminoglycosides.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/20.6.825