Management of first-trimester miscarriage: a systematic review and network meta-analysis

Abstract BACKGROUND First-trimester miscarriage affects up to a quarter of women worldwide. With many competing treatment options available, there is a need for a comprehensive evidence synthesis. OBJECTIVES AND RATIONALE We conducted a systematic review and network meta-analysis to assess the effec...

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Veröffentlicht in:	Human reproduction update 2019-05, Vol.25 (3), p.362-374
Hauptverfasser:	H. Al Wattar, Bassel, Murugesu, Nilaani, Tobias, Aurelio, Zamora, Javier, Khan, Khalid S
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortifacient Agents, Nonsteroidal - administration & dosage Abortifacient Agents, Steroidal - administration & dosage Abortion, Spontaneous - therapy Female Gestational Age Humans Mifepristone - administration & dosage Misoprostol - administration & dosage Network Meta-Analysis Pregnancy Pregnancy Trimester, First Vacuum Curettage - methods
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Zusammenfassung:	Abstract BACKGROUND First-trimester miscarriage affects up to a quarter of women worldwide. With many competing treatment options available, there is a need for a comprehensive evidence synthesis. OBJECTIVES AND RATIONALE We conducted a systematic review and network meta-analysis to assess the effectiveness and safety of treatment options for first-trimester miscarriage: expectant management (EXP), sharp dilation and curettage (D+C), electric vacuum aspiration (EVAC), manual vacuum aspiration (MVA), misoprostol alone (MISO), mifepristone+misoprostol (MIFE+MISO) and misoprostol plus electric vacuum aspiration (MISO+EVAC). SEARCH METHODS We searched MEDLINE, Embase, CINAHL, AMED and Cochrane Library from inception till June 2018. We included randomized trials of women with first-trimester miscarriage (
ISSN:	1355-4786 1460-2369
DOI:	10.1093/humupd/dmz002