O-175 Failed thaw cycles (FThC) as a key performance indicator (KPI): accounting for patient diagnosis and preimplantation genetic testing (PGT)

Abstract Study question Does the presence of a specific infertility diagnosis, in addition to PGT, impact FThC and live birth rate (LBR)? Summary answer Infertility diagnoses (Dx) and PGT should be taken into consideration when developing and/or evaluating FThC KPIs. What is known already FThC (ie, percentage of thaw procedures that failed to produce any embryos suitable for transfer) has been suggested as a KPI for laboratory competency in freezing/thawing procedures. Previous analyses showed that PGT (including testing for aneuploidy, monogenic/single gene defects, and structural chromosome rearrangements) was associated with improved proportions of FThC and LBRs. Here, we examined whether the presence of specific Dx could further impact the extent of improvement related to PGT on FThC and LBR. Study design, size, duration Retrospective real-world data analyses were performed using 6 years of available data from the Society for Assisted Reproductive Technology (SART) United States Registry between 2014–2019. Data analyses, including a descriptive review, focused on the following 5 Dx: diminished ovarian reserve (DOR), endometriosis (E), ovulatory dysfunction (OD), male factor (MF), and unknown factor (UF). These Dx were chosen based on the high prevalence of thaw cycles and/or historical difficulty to treat. Participants/materials, setting, methods A total of 9393 thaw cycles were analyzed, including the first transfer ≥12 months after retrieval, second transfer, or later transfers, given the database output limitation (fresh and frozen transfers taking place