Genomic organization of human histo-blood group ABO genes

We have isolated human genomic DNA clones encompassing 30 kbp of the histo-blood group ABO locus. The locations of the exons have been mapped and the nucleotide sequences of the exon-intron boundaries have been determined. The human ABO genes consist of at least seven exons, and the coding sequence...

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Veröffentlicht in:	Glycobiology (Oxford) 1995-02, Vol.5 (1), p.51-58
Hauptverfasser:	Yamamoto, Fumi-ichiro, McNeill, Patricia D., Hakomori, Sen-itiroh
Format:	Artikel
Sprache:	eng
Schlagworte:	ABO ABO Blood-Group System - genetics Animals Base Sequence DNA Primers Exons Galactosyltransferases - genetics genomic Genomic Library glycosyltransferase histo-blood group Hominidae - genetics Humans Introns Molecular Sequence Data Polymerase Chain Reaction Promoter Regions, Genetic Repetitive Sequences, Nucleic Acid Restriction Mapping RNA Splicing Sequence Homology, Nucleic Acid transfusion
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Beschreibung
Zusammenfassung:	We have isolated human genomic DNA clones encompassing 30 kbp of the histo-blood group ABO locus. The locations of the exons have been mapped and the nucleotide sequences of the exon-intron boundaries have been determined. The human ABO genes consist of at least seven exons, and the coding sequence in the seven coding exons spans over 18 kb of the genomic DNA. The exons range in size from 28 to 688 bp, with most of the coding sequence lying in exon 7.
ISSN:	0959-6658 1460-2423
DOI:	10.1093/glycob/5.1.51