P1544Circulating secretoneurin concentrations provide incremental prognostic information to established risk indices in patients with moderate to severe aortic stenosis

Abstract Background Secretoneurin (SN) concentrations provide important prognostic information in patients with myocardial dysfunction. Whether preoperative SN concentrations improve risk assessment in patients with moderate to severe aortic stenosis (AS) is unknown. Methods We included 57 patients with moderate to severe AS referred for presurgical evaluation and recorded all-cause mortality during follow-up. All patients were examined with comprehensive echocardiography, electrocardiogram (ECG), and high-sensitivity cardiac troponin T (hs-TnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurements. Results Median (quartile 1–3) SN concentration in the AS patients was 141 (121–163) pmol/L. Lower estimated creatinine clearance and use of diuretics, but not standard ECG or echocardiographic indices and cardiac biomarkers, were associated with increasing SN concentrations. In total, 15 patients (26%) died during 3.5 years median follow-up. SN concentrations were higher in non-survivors than survivors: 156 (133–209) vs. 140 (116–155) pmol/L, p=0.007. The optimal cut-off concentration for SN in discriminating long-term mortality was 147 pmol/L (sensitivity 67% [95% CI 38–88%], specificity 74% [58–86%]) and patients with SN concentrations above the optimal cut-off had worse prognosis than patients below the cut-off (Figure; p=0.005 with the log-rank test). Higher SN concentrations were associated with increased risk of mortality after adjustment for clinical risk factors, echocardiographic and ECG variables, hs-TnT and NT-proBNP concentrations, and whether patients were subjected to aortic valvular surgery (n=34): hazard ratio per lnSN 15.13 (95% CI 1.05–219.00); p=0.046. Receiver operating characteristics area under the curve for SN to predict mortality was 0.74 (95% CI 0.60–0.88) compared to 0.73 (0.59–0.87) for hs-TnT and 0.67 (0.51–0.82) for NT-proBNP. Conclusions SN concentrations seem to reflect additional pathophysiology to established risk indices and improve risk assessment in patients with moderate to severe AS.