Use of a wearable patch sensor for continuous activity and posture tracking to assess risk of early infection after transcatheter aortic valve replacement

Abstract Background Early infections after transcatheter aortic valve replacement (TAVR) represent one of the most common risk factors for non-cardiac 30-day mortality. Several wearable devices have been developed to measure vital signs and physical activity in real time while allowing full mobilization of the patient. However, their use has not been evaluated in a clinical setting with patients undergoing TAVR yet. Purpose We aimed to evaluate the feasibility of wearable patch sensors in assessing vital signs and daily activity before and after TAVR to predict an increased risk of early infections following TAVR. Methods Patients at high risk for infection undergoing transfemoral TAVR under local anesthesia were enrolled between September 2022 and January 2023. Postprocedural early infections were assessed, defined as C-reactive protein rise within 5 days after the procedure inducing antibiotic treatment. Vital signs (heart rate, respiratory rate, single-lead ECG) and activity (steps, posture) were monitored by a wearable patch sensor two days before (pre-TAVR) and two days after TAVR (post-TAVR). Results 54 patients completed 5 days of in-hospital monitoring with wearable patch sensors. The mean age was 80.3+5.2 years, 31 patients (57.4%) were male. Early infections occurred in 8 of 54 (14.8%) high-risk patients, of whom one was a urinary tract, one a pulmonary, and two access site-related etiology. Four infections remained with unknown focus. Respiratory rate was generally higher in patients developing an early infection after TAVR in both time periods, before (early infection 22±3 vs. no infection 18±2 bpm; p=0.001) and after TAVR (early infection 24±3 vs. no infection 19±3 bpm; p