High-sensitivity c-reactive protein to high-density lipoprotein cholesterol ratio and the risk of contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention

Abstract Background High-sensitivity C-reactive protein to high-density lipoprotein cholesterol ratio (CHR) is a new biomarker, which is related to the incidence rate of coronary artery disease (CAD). The purpose of this study was to investigate the association between CHR and contrast-induced acute kidney injury (CI-AKI). Methods In this retrospective cross-sectional study, 10,917 patients underwent PCI. Diagnose CI-AKI according to KIDIGO standard. Univariate and multivariable logistic regression analysis were used to determine the relationship between CHR and CI-AKI, and further draw the receiver operating characteristic (ROC) curve of subjects to evaluate the clinical diagnostic performance of CHR on CI-AKI. Results 1,037 patients (9.50%) developed CI-AKI after PCI. The subjects were 64.1 ± 11.1 years old, 2,511 were females (23.0%). Multivariate logistic regression analysis showed that the increase of CHR level was associated with the increase of CI-AKI incidence rate ([Q4 vs. Q1]: odds ratio (OR) = 1.89, 95% confidence interval (CI) [1.42 to 2.54], P < 0.001). Restrictive cubic spline analysis showed that CHR and CI-AKI were linear relationship. ROC analysis confirmed that CHR was a good predictor of CI-AKI (area under ROC curve =0.606, 95% CI [0.588 to 0.624]). Conclusions High CHR level is closely related to the increase of CI-AKI incidence, indicating that CHR may be an independent risk factor of CI-AKI.