The impact of diabetes mellitus on improvement of resting rate pressure product in patients with refractory angina undergone external counter pulsation

Abstract Funding Acknowledgements Type of funding sources: None. Background The management of coronary artery disease (CAD) has developed significantly in the last few decades. One of the therapeutic modalities that could be considered to patients with refractory angina caused by CAD is external counter pulsation (ECP). Rate pressure product (RPP) is a determinant of cardiac oxygen consumption and heart workload. It is a simple parameter that could be calculated easily by multiplying systolic blood pressure and heart rate. Increased resting RPP is associated with higher myocardial oxygen consumption and decreased cardiac efficiency. Studies that discuss factors that influence the decrease of resting RPP due to ECP procedure as a possible mechanism underlying the improvement of clinical symptoms in patients with refractory angina are still very limited. Purpose This study aimed to determine the impact of diabetes mellitus (DM) as one of most common risk factors for complex CAD and refractory angina on the decremental of resting RPP in refractory angina patients who have undergone standard 35 sessions of ECP. Methods This is a cohort retrospective study that collected data from registry of all patients who have completed 35 sessions of ECP procedures from 2018 until 2021. We compared the improvement of resting RPP after program completion and evaluated the effect of DM and blood glucose levels on the difference in resting RPP. Statistical test was performed by SPSS software for windows. Results A total of 16 patients were enrolled in this study with mean age of 65.4 years old. Subjects in this study were predominantly male (87.5%) and most of the subjects (68.8%) were diagnosed with CAD/3-vessels disease (3VD). The main risk factors found in the subjects were hypertension (75%) and DM (62.5%). All subjects underwent random blood sugar examination before starting ECP procedure with mean 122.7 mg/dL. Paired samples T-test analysis found that there was a decrease in resting RPP in subjects after undergoing ECP compared to before the procedure (7046.1 ± 1515.3 vs 8572.5 ± 1915.7; p-value