Predictive value of cardiac troponin increase after percutaneous coronary intervention: is it just a marker of disease complexity?

Abstract Background/Introduction Peri-procedural myocardial infarction (MI) following percutaneous coronary intervention (PCI) is supposed to have an impact on outcome after PCI for stable coronary disease, but the rate of this event is highly dependent on their definitions. Most of the recently proposed definitions are based on cardiac troponin (hs-cTn) rise. Purpose The purpose of this analysis is to explore the impact of hs-cTn increase on mortality and cardiac events after PCI for chronic coronary disease with baseline normal value of hs-cTn. Methods e-ULTIMASTER is a large, all-comers registry that enrolled 37,198 patients worldwide who underwent PCI with a thin strut, cobalt chromium sirolimus-eluting stent. Risk-based monitoring was performed and all primary endpoint related events were adjudicated. Clinical follow-up was performed at 3 months and 1 year, with primary endpoint of target lesion failure (TLF) at 1 year. For this analysis, we selected patients with stable angina, silent ischemia, or unstable angina with normal hs-cTn values at baseline. We defined the cut-off value of hs-cTn level as the following: