Prognostic impact of significant mitral regurgitation in patients with severe low flow, low gradient aortic stenosis undergoing transcatheter aortic valve replacement

Abstract Funding Acknowledgements Type of funding sources: None. Aim The aim of this study was to determine the prevalence and prognostic implications of MR severity in patients with LFLG-AS undergoing TAVR, and to evaluate whether the improvement of MR after procedure could influence 1-year outcome. Methods All consecutive patients with severe LFLG-AS undergoing TAVR in two high-volume Italian centres from 2017 to 2022 were prospectively included. LFLG-AS was defined as indexed aortic valve area (AVAì) ≤0.6 cm2/m2; mean gradient 2+ showed a significantly higher NYHA class at admission (p = 0.001); higher EuroSCORE II (p2+ showed a significantly higher percentage of the primary outcome (p