The Gly460Trp polymorphism and the overnight sodium potassium excretion in hypertensives
Abstract Introduction The Gly460Trp polymorphism is associated to hypertension and renal sodium (Na) potassium (K) exchange. This study explores the relationship between blood pressure (BP) and urinary overnight Na/K ratio (UONaK) in patients genotyped for Gly460Trp polymorphism, from a cohort of hy...
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| Veröffentlicht in: | European heart journal 2020-11, Vol.41 (Supplement_2) |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
Introduction
The Gly460Trp polymorphism is associated to hypertension and renal sodium (Na) potassium (K) exchange. This study explores the relationship between blood pressure (BP) and urinary overnight Na/K ratio (UONaK) in patients genotyped for Gly460Trp polymorphism, from a cohort of hypertensive (HT) and normotensive (NT) subjects from National Heart, Lung and Blood Institute funded, Family Blood Pressure Program (FBPP).
Hypothesis
Abnormal renal K and Na excretion is associated to the Trp allele of Gly460Trp polymorphism.
Methods
3,545 subjects genotyped for Gly460Trp polymorphism were analyzed from FBPP. Subjects with diastolic BP (DBP) ≥80 or systolic BP (SBP) ≥130 mmHg were classified HTN; subjects with SBP |
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| ISSN: | 0195-668X 1522-9645 |
| DOI: | 10.1093/ehjci/ehaa946.2703 |