Clinical and imaging predictors of recovery in patient with pulmonary emboli

Abstract Background Post-pulmonary emboli impairment (PPEI), comprised significant morbidity and mortality. A single center registry of patients with PE was established in order to estimate patients' risk, monitor clinical management and develop a simple model to assess the risk for PPEI for the entire spectrum of patients treated in general clinical practice. Methods For developing the mentioned model, apart from approved imaging parameters, potential novel imaging parameters were also evaluated. Recovery were assessed according to Pulmonary Embolism Thrombolysis (PEITHO) trial definition (Figure 1). Results 140 patients have been registered with at least 6-month imaging follow up. PPEI was confirmed in 75 (53.6%) patients with PE. The prognostic value of traditional and novel imaging parameters on 6-month complete recovery were summarized in Table. A multivariable logistic regression model was developed using 140 patients. Previous PE, HRfollowing five in-hospital-parameters accounted for simple prognostic model for incomplete recovery: history of PE, heart rate≥110, serum blood urea nitrogen level, RV/LV ratio and right atrium area, The overall prediction ability was excellent with 80.6 overall percentage for PPEI. Conclusions PPPEI rate was considerable in our study. Our proposed simple prediction model might have a role on identification of patients at risk for PPEI. Prognostic value of novel parameters Imaging modalities Parameters Baseline parameters in patients with 6-month complete recovery Baseline parameters in patients with 6-month incomplete recovery P value 95% CI of the Difference (N=65) (N=75) Lower Upper Pulmonary computed tomography angiography Main PA (mm) (mean ± SD) 28.10±3.75 30.24±4.03 0.005 −3.62 −0.66 Qanadli score (mean ± SD) 16.83±6.77 19.83±5.81 0.016 −5.43 −0.568 SVC (mm) (mean ± SD) 19.96±3.74 22.10±3.76 0.004 −3.57 −0.71 RV to LV ratio (mean ± SD) 1.07±0.29 1.31±0.33