The relevance of hs-troponin and global longitudinal strain in predicting the need for mechanical intubation in severe COVID-19 patients

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Dr.Soetomo General Hospital Abbott Background The occurrence of an imbalance in oxygen supply results in the release of pro-inflammatory cytokines which leads to increased ventilation support requirement. Half of the intubated patients with COVID-19 manifest myocardial injury, which is associated with a graded increase in overall mortality. Purpose This study aims to analyze factors that contribute to worse outcomes among severe COVID-19 infections. Methods We performed an observational, single-center prospective cohort study from February 1st – July 31st, 2021 at an Isolated ICU. A total of 65 subjects were included. Subjects were recruited according to WHO criteria for severe COVID-19 and CDC criteria for myocarditis. All subjects recruited were examined using echocardiography to measure global longitudinal strain (GLS) and blood samples were taken to measure hs-Troponin. Subjects were then followed to assess their needs for mechanical ventilation and in-hospital mortality. Results Severe COVID-19 subjects with cardiac injury were associated with an increased need for intubation (78.5%) and an increased incidence of myocarditis (50.8%). There was an association between the use of intubation and the risk of mortality in patients (66.7% vs. 33.3%, p-value