Comparative analysis of ischemic and non-ischemic etiology of acute heart failure - analysis from the "OP-AHF" registry

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): This work was supported by a grant from the Institute of Medical Sciences, University of Opole, Poland. ROCHE Diagnostics Poland. Introduction Current guidelines of the European Society of Cardiology define acute heart failure as the rapid onset of symptoms and/or signs of heart failure, severe enough for the patient to seek urgent medical attention, leading to an unplanned hospital admission or an emergency department visit. Purpose The aim of this study was to compare clinical characteristics, treatment, and 12-month outcomes of patients with ischemic(I-AHF) and non-ischemic acute heart failure(NI-AHF). Materials and Methods As a part of the open prospective Acute Heart Failure Registry (OP-AHF),data 122 patients hospitalized in the Intensive Cardiac Care Unit were collected in the period from June 2019. The inclusion criteria were hospitalization for acute heart failure and the need to use at least one of: intravenous diuretics, catecholamines or mechanical circulatory support. The project was approved by the Bioethical Committee. Results Patients with ischemic etiology of acute heart failure (I-AHF) constituted 43% of the study group (53 of 122 patients). Compared to patients with non-ischemic etiology of acute heart failure (NI-AHF), patients with I-AHF were older (69 vs. 64 years, p = 0.04) and slightly more frequently male (79% vs. 67%, p=0.12). BMI was similar in both groups (29 vs. 30, p=0.21). On admission, they reported more frequently chest pain (49% vs. 33%, p = 0.08), and less frequently than NI-AHF patients, edema (40% vs. 54%, p = 0.12) and dyspnoea (91% vs. 97%, p =0.25). History of diabetes (60% vs. 20%, p