P813 Pregnancy, postpartum and health of newborn in patients with inflammatory bowel disease: experience at a single-centre

Abstract Background Inflammatory bowel disease (IBD) affects young women. According to the evidence, IBD does not affect fertility. It is advisable to plan conception in quiescent phase. Aim: development of pregnancy, postpartum and activity of the disease. Effect of maternal disease in the health of the newborns. Methods Retrospective descriptive study. Database from patients of the Hospital Universitario San Cecilio of Granada (Spain). Electronic clinical records between 2012 and 2017 have been reviewed. Results There were 68 pregnancies. Description of the population in Table 1. Mean age from diagnosis to pregnancy is 8.83 years. Variable Frequency Number of pregnancies: 1; ≥2 37 women; 13 women Maternal age (years old): < 35; ≥35 39 (57.35%); 29 (42.65%) Smoking mothers 13% Type of disease: Ulcerative colitis (UC) (Pancolitis; Recto sigmoiditis; Proctitis, Unknown extension), Crohn’s disease (CD) (Ileocolitis; Ileal; Colitis; Antroduodenal and ileocolitis; Unknown extension; Perianal disease) 32 patients (47.06%) (16.65%; 37.49%; 28.12%; 18.74%), 36 patients (52.94%) (55.56%; 25%; 13.88%; 2.78%; 2.78%; 22.22%) Treatment: mesalazine; thiopurines; anti-TNF; without treatment 46.87%; 23.44%; 18.75%; 10.94% Characteristics of the population. Of the 68 pregnancies, 10 women (14.71%) had history of surgery due to IBD, all of them with Crohn’s disease (CD). In conception, 8/10 were in quiescent phase. During pregnancy, 17.65% of patients stopped their treatment on own initiative or indication of the general practitioner. In all patients anti-TNF could be suspended in the third trimester. There were seven flare-up (10.29%), and all of them were controlled with corticosteroids. 10.29% women had other complications during pregnancy, but only one was due to IBD (severe thrombocytopenia in a patient in treatment with azatioprine which needed caesarean section). There were two induced abortion and six early miscarriage, being 75% in CD patients. Most were full-term newborns, there were only three late preterm infants in women with CD. The labour was vaginal delivery in 53 cases and caesarean section in 15 (22.06%), three of them due to perianal disease, and the rest for obstetric reasons. Only one newborn (1.47%) was small for gestational age, they was one of the twins of a multiple gestation. 69.12% mothers were breastfeeding, more frequent in ulcerative colitis (UC) (81,25%) than CD (41,67%). Any newborn from mothers with UC had any relevant disease, but there we