P240 Surgical resection in a tertiary IBD centre in Southeastern Brazil: clinical aspects and associated factors

Abstract Background Despite the numerous advances in medical treatment, it is estimated that a significant percentage of patients with IBD requires bowel resection at least once. The aim of this study was to evaluate patient characteristics and factors associated to surgical resection in patients with IBD in a tertiary IBD unit in Southeastern Brazil. Methods Retrospective analysis of data from 446 patients with IBD in follow-up at the University Hospital, Ribeirão Preto Medical School, from January 2000 up to December 2016. Medical records data comprised age, gender, disease type (Crohn’s disease [CD] or ulcerative colitis [UC]), disease location, disease behaviour, disease duration and smoking. Patients were divided into two groups: presence or absence of surgical resection. Results Out of the 446 patients, 143 (111 CD and 32 UC) underwent surgical resection (53.2% female, 82.9% Caucasians, mean age: 45.49 ± 13.30 years). Main indications for surgery were: stenosis (10.3%), clinical intractability (6.5%) and massive haemorrhage (2.7%). Smoking (p = 0.0109, OR = 2.244; 95% CI: 1.237 to 4.056), stenotic phenotype (p < 0.0001, OR = 5.294; 95% CI: 3.073 to 9.1212), ileo-colonic location (p < 0.0001, OR = 3.447; 95% CI: 2.061 to 5.698) and longer disease duration (15.17 ± 9.19 vs. 7.94 ± 5.96 years) [p < 0.0001] were significantly associated with operations for CD. Longer duration (21.15 ± 21.58 vs. 9.79 ± 7.08 years) [p < 0.0001] and pancolitis (p = 0.0014; OR = 3.823; 95% CI: 1.698–8.605) were associated with surgical resection in UC. This results are summarised in Tables 1 and 2. Variable OR (95% CI) p-Value Smoking 2.244 (1.237–4.056) 0.0109 Stenotic phenotype 5.294 (3.073–9.1212)