P750 Predictors of quick remission after cyclosporine A therapy in Paediatric ulcerative colitis

Abstract Background Cyclosporin A is a second-line drug in ulcerative colitis that failed to respond to intravenous glucocorticoids according to ECCO/ESPGHAN consensus . Up-to-date CsA induced mucosal healing (Mayo 0 score) is the only factor predicting the lack of course deterioration in the future. The aim of the study was to investigate a presence of factors contributing to positive CsA therapy outcome. Methods It is a retrospective, single center study. We describe a clinical characteristic of 59 children (33 females, 26 males), mean age of 13.7 years, mean disease duration 32 months, who underwent CsA treatment in the course of UC in years 2005–2015. The primary endpoint was clinical remission (defined as PUCAI