P651 Reliability of blood tests, neutrophil lymphocyte ratio (NLR) and Glasgow prognostic index (GPI) to evaluate the severity of the Crohn’s disease

Abstract Background The blood tests are used in recent years to detect the severity of the chronic diseases (CD). White blood cell (WBC), lymphocyte (L), platelet (Plt), C-reactive protein (CRP), neutrophil (N), albumin (Alb), platelet neutrophil ratio (PNR), neutrophil lymphocyte ratio (NLR) are good markers to predict the severity of the inflammatory bowel diseases and postoperative morbidity rate of gastrointestinal surgery. We aimed to evaluate predictive accuracy of the markers above in respect of length of hospital stay (LOS) for the active CD. Methods The medical records of consecutive patients who were operated in our clinic between 2012 and 2017 with a diagnosis of CD were reviewed retrospectively. Forty-three patients with intraabdominal abscess, enterocutaneous fistula or enteroenteric fistula were included in the study. WBC, L, platelet, CRP, N, A, PNR, NLR values were recorded from the file charts. The Glasgow prognostic index (GPI) and length of the postoperative stay in hospital were also recorded. The effect of the parameters to the major morbidity rates and the LOS was evaluated statistically. Results The mean age was 41.5 (19–66) years and 28 patients (65.1%) were male. The mean LOS was 8.1 (3–30) days. Three major (6, 0%) and seven minor complications (16, 2%) were detected in the study group. The mean values of the parameters were: Alb = 3.3 g/dl, CRP = 4.7, WBC: 9.2/dl, L: 1.78/dl, platelet = 379000/dl, N = 6.5/dl, haemoglobin = 11.7 g/dl, PNR = 67.5, NLR = 5.2. The GPI was found 0, 1, and 2 in 11, 12, and 20 patients, respectively. The L count and NLR value were significantly predictive markers for the LOS (p < 0.05). The other parameters were ineffective to predict the LOS. The statistical effect of the parameters on the complications were not researched because the morbidity rate was low. Conclusions Elevated PNR and L count were associated with prolonged length of post-operative hospital stay in the patients with complicated active CD. NLR and L count are reliable markers to predict the severity of the CD.