P241 Predictive factors of bone loss in inflammatory bowel disease

Abstract Background Patients with inflammatory bowel disease (IBD) are at increasing risk of developing disorders in bone and mineral metabolism. Osteopenia and osteoporosis are frequent but often underestimated complications in these patients. Several factors could contribute to osteopenia, but the pathogenetic mechanisms are still not completely understood. The aim of this study is to assess the prevalence and the risk factors associated with bone loss in IBD patients. Methods We conducted a retrospective study from January 2007 to June 2012, including all patients with IBD who attended our department. Bone mineral density (BMD) was measured with diphotonic x-ray absorptiometry of the lumbar spine and the neck of the left femur. Results were expressed as T score (osteopenia: −2.5 standard deviation (SD) < T< -1 SD, osteoporosis: T 4.5 g of Prednisone (p = 0.001). In multivariate analysis, the following factors were independently predictive of bone loss: limited physical activity (p = 0.013), body mass index