522. MULTI-SLICE, VOLUMETRIC COMPUTED TOMOGRAPHY BODY COMPOSITION ANALYSIS IN PATIENTS WITH OESOPHAGOGASTRIC CANCER

Abstract Background Single-slice computed tomography (CT) body composition has been studied extensively for prognostication in patients with cancer. New software packages can also provide multi-slice volumetric measurements, but the clinical utility of these remains under explored. This study aimed to evaluate the concordance between single- and multi-slice body composition analyses in patients with oesophagogastric cancer, and to explore the association between these measures and overall survival. Methods Consecutive patients with newly diagnosed oesophagogastric cancer were identified through the prospectively maintained regional database of the South-East Scotland Cancer Network across a 2-year study period. CT body composition analyses were undertaken using scans collected during routine clinical care. Single-slice (cross-sectional area at mid L3) and multi-slice (volume between T12-L4) measurements were obtained for skeletal muscle (SKM), subcutaneous adipose (SAT), visceral adipose (VAT) and intermuscular adipose (IMAT). Agreement between sex-stratified z-scores was quantified using Pearson correlation coefficients and Bland–Altman analyses. Cox proportional hazard modelling was used to estimate the effect of these measures on overall survival. Results Overall, 504 patients (67.9% male, median 72 years) were newly diagnosed with oesophagogastric cancer during the study period. Treatment was commenced with curative intent for 131 patients (26.0%). Single-slice area and multi-slice measurements were highly correlated for SKM (R: 0.97, p