135. IMPACT OF GENDER, RACE AND AGE OF ONSET ON THE PHENOTYPE AND COMORBIDITIES OF PEDIATRIC EOSINOPHILIC ESOPHAGITIS

Abstract Eosinophilic esophagitis (EoE) is recognized as chronic immunologic disorder of the esophagus resulting in esophageal inflammation by the accumulation of eosinophils in the epithelium. Several risk factors are thought to be associated with the development of EoE, but because of its complex underlying mechanisms of disease, there is little clarity in regards to the different symptoms experienced, pathological findings and associated comorbidities including atopic and allergic disorders between different gender, race and age of onset. This study utilized a retrospective chart review on the patients seen by a multidisciplinary EoE clinic from January 2020 to December 2022. Subjects were diagnosed with EoE, and retrospectively assessed for eosinophilic counts on the initial distal and proximal esophageal biopsies, and previously specified symptoms and comorbidities. The differences of eosinophilic counts, associated symptoms and comorbidities between gender (male or female), race (White or non-White) and age of onset (≤ 6 years old is defined as early onset, or > 6 years old is defined as regular onset in this study), were statistically analyzed by t-test or Chi-Square. P