Selective effects of pentobarbital on automaticity and conduction in the intact canine heart

The effects of sodium pentobarbital on automaticity and conduction were studied in dogs anaesthetized with three different agents. Pentobarbital was administered selectively through the nutrient arteries of the sinus node and AV junction. Interplay with directly administered and neurally released au...

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Veröffentlicht in:	Cardiovascular research 1974-01, Vol.8 (1), p.46-57
Hauptverfasser:	URTHALER, FERDIN, KRAMES, BARBARA L., JAMES, THOMAS N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Anesthesia Animals Atropine - pharmacology Blood Pressure Chloralose Depression, Chemical Dogs Electric Stimulation Electrocardiography Heart Block - chemically induced Heart Conduction System - drug effects Heart Rate - drug effects Ketamine Norepinephrine - pharmacology Pentobarbital - pharmacology Propranolol - pharmacology Reserpine - pharmacology Sinoatrial Node - drug effects Tyramine - pharmacology Vagus Nerve - physiology
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Zusammenfassung:	The effects of sodium pentobarbital on automaticity and conduction were studied in dogs anaesthetized with three different agents. Pentobarbital was administered selectively through the nutrient arteries of the sinus node and AV junction. Interplay with directly administered and neurally released autonomic neurotransmitters was assessed. The electrophysiological effects were exclusively negative, impairing both impulse formation and conduction, independent of the anaesthetic chosen.
ISSN:	0008-6363 1755-3245
DOI:	10.1093/cvr/8.1.46