Relation of platelets to catecholamine induced myocardial injury

To test the thesis that myocardial injury, induced by catecholamines, is ischaemic in origin due to platelet accumulation in the coronary microvasculature, sustained left intracoronary and systemic infusion of catecholamines in toxic dosage was given to dogs previously infused with autologous 51Cr-l...

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Veröffentlicht in:	Cardiovascular research 1978-04, Vol.12 (4), p.243-246
Hauptverfasser:	MOSCHOS, CHRISTOS B., HAIDER, BUNYAD, KHAN, YUSUF, LYONS, MICHAEL M., REGAN, TIMOTHY J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Coronary Circulation - drug effects Dogs Epinephrine - administration & dosage Epinephrine - pharmacology Heart Diseases - chemically induced Injections, Intra-Arterial Norepinephrine - administration & dosage Norepinephrine - pharmacology Platelet Aggregation - drug effects
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Beschreibung
Zusammenfassung:	To test the thesis that myocardial injury, induced by catecholamines, is ischaemic in origin due to platelet accumulation in the coronary microvasculature, sustained left intracoronary and systemic infusion of catecholamines in toxic dosage was given to dogs previously infused with autologous 51Cr-labelled platelets. Subsequent determination of tissue radioactivity and electrolytes, as well as electronmicrography, indicated that the induced myocardial injury was not related to microvascular occlusion by platelets.
ISSN:	0008-6363 1755-3245
DOI:	10.1093/cvr/12.4.243