Use of High Pressure Liquid Chromatography for the Separation of Drugs of Abuse

Use of High Pressure Liquid Chromatography for the Separation of Drugs of Abuse

Methods for the separation of drugs of abuse based on high pressure liquid chromatography have been developed. One of these, a gradient system, can, within 30–40 minutes, separate 16 common street drugs including phencyclidine (PCP), methadone, cocaine, tetrahydrocannabinol (THC), methamphetamine, 2...

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Veröffentlicht in:Journal of chromatographic science 1974-09, Vol.12 (9), p.512-516
Hauptverfasser: Chan, M L, Whetsell, C, McChesney, J D
Format: Artikel
Sprache:eng
Schlagworte:
Amphetamines - analysis
Barbiturates - analysis
Chromatography - methods
Cocaine - analysis
DOM 2,5-Dimethoxy-4-Methylamphetamine - analysis
Dronabinol - analysis
Hallucinogens
Heroin - analysis
Humans
Hypnotics and Sedatives - analysis
Lysergic Acid Diethylamide - analysis
Mescaline - analysis
Methadone - analysis
Phencyclidine - analysis
Pressure
Psychotropic Drugs - analysis
Solvents
Spectrum Analysis
Substance-Related Disorders
Tryptamines - analysis
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Zusammenfassung:Methods for the separation of drugs of abuse based on high pressure liquid chromatography have been developed. One of these, a gradient system, can, within 30–40 minutes, separate 16 common street drugs including phencyclidine (PCP), methadone, cocaine, tetrahydrocannabinol (THC), methamphetamine, 2,5-dimethoxy-4-methylamphetamine (STP), methylenedioxyamphetamine (MDA), heroin, N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), Valium, mescaline, secobarbital, amobarbital, phenobarbital and Dilantin. Adsorption and partition chromatography were both investigated. Adsorption chromatography on Corasil II or Supelcosil-ATF 230 was found to be the most useful and was directly quantifiable. Employment of high pressure liquid chromatography as a preliminary purification to spectral identification of specific drugs was found to be very useful.
ISSN:0021-9665
1945-239X
DOI:10.1093/chromsci/12.9.512