Synthesis and Structural Characterization of Benzene-1,3-disulfonamide-containing 11- to 13-membered Heterocycles via Double Mitsunobu Annulation

Synthesis and Structural Characterization of Benzene-1,3-disulfonamide-containing 11- to 13-membered Heterocycles via Double Mitsunobu Annulation

The synthesis and conformation of several novel benzene-1,3-disulfonamides-containing 11- to 13-membered heterocycles have been achieved. Double Mitsunobu annulation was effective for construction of medium to large ring systems in moderate chemical yields. In addition, the flexibility of sulfonamid...

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Veröffentlicht in:Chemistry letters 2024-01
Hauptverfasser: Kaneda, Kyosuke, Koideya, Takato, Toshima, Ryuji, Konno, Yoshiki, Yamagishi, Takehiro
Format: Artikel
Sprache:eng
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Zusammenfassung:The synthesis and conformation of several novel benzene-1,3-disulfonamides-containing 11- to 13-membered heterocycles have been achieved. Double Mitsunobu annulation was effective for construction of medium to large ring systems in moderate chemical yields. In addition, the flexibility of sulfonamide moieties in these rings was determined by X-ray crystal structural analysis.
ISSN:0366-7022
1348-0715
DOI:10.1093/chemle/upad016