Effect of D,L-α-difluoromethylornithine on murine mammary carcinogenesis

The development of chemically-induced mammary gland carcinomas in rats was dramatically suppressed by provision of a 1% solution of D,L-α-difluoromethylornithine (DFMO) in drinking water. Treatment with DFMO significantly reduced cancer incidence and the average size and number of cancers per rat an...

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Veröffentlicht in:	Carcinogenesis (New York) 1984-12, Vol.5 (12), p.1649-1651
Hauptverfasser:	Thompson, Henry J., Herbst, Edward J., Meeker, L. David, Minocha, Rakesh, Ronan, Anne M., Fite, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Eflornithine Female Mammary Neoplasms, Experimental - analysis Mammary Neoplasms, Experimental - prevention & control Medical sciences Ornithine - analogs & derivatives Ornithine - therapeutic use Ornithine Decarboxylase Inhibitors Polyamines - analysis Rats Rats, Inbred Strains Tumors
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Beschreibung
Zusammenfassung:	The development of chemically-induced mammary gland carcinomas in rats was dramatically suppressed by provision of a 1% solution of D,L-α-difluoromethylornithine (DFMO) in drinking water. Treatment with DFMO significantly reduced cancer incidence and the average size and number of cancers per rat and prolonged the cancer-free time. DFMO appears to be effective in blocking some aspect of the promotion stage of chemically induced mammary carcinogenesis in the rat.
ISSN:	0143-3334 1460-2180
DOI:	10.1093/carcin/5.12.1649