Manganese inhibition of sarcoma induction by benzo[a]pyrene in rats

The effects of Mn and Cr dusts upon carcinogenesis by polycyclic aromatic hydrocarbons were tested in male Fischer 344 rats. In Experiment I, rats were given i.m. injections of benzo[a]pyrene (BP, 1.2 mg), Mn dust (4.4 mg), and Cr dust (4.4 mg), alone, and in various combinations. By 100 weeks, sarc...

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Veröffentlicht in:	Carcinogenesis (New York) 1980-07, Vol.1 (7), p.613-620
Hauptverfasser:	Sunderman, F.William, McCully, Kilmer S., Taubman, Sheldon B., Allpass, Patricia R., Reid, Marilyn C., Rinehimer, Lois A.
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Anticarcinogenic Agents - pharmacology Benzo(a)pyrene - antagonists & inhibitors Benzo(a)pyrene - toxicity Carcinogens - antagonists & inhibitors Carcinogens - toxicity Chromium - pharmacology Drug Interactions Dust Injections, Intramuscular Male Manganese - pharmacology Rats Rats, Inbred F344 Sarcoma, Experimental - chemically induced Sarcoma, Experimental - prevention & control
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Zusammenfassung:	The effects of Mn and Cr dusts upon carcinogenesis by polycyclic aromatic hydrocarbons were tested in male Fischer 344 rats. In Experiment I, rats were given i.m. injections of benzo[a]pyrene (BP, 1.2 mg), Mn dust (4.4 mg), and Cr dust (4.4 mg), alone, and in various combinations. By 100 weeks, sarcomas occurred at the injection site in 17/20 rats that received BP alone, versus 10/19 rats that received BP plus Mn dust (P
ISSN:	0143-3334 1460-2180
DOI:	10.1093/carcin/1.7.613