SHORT COMMUNICATION: Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe—NTA)
A significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) was observed in the kidney DNA of rats given a renal carcinogen, the ferric complex of nitrilotriacetate (Fe—NTA) by single i.p. injection. By contrast, non- or weakly carcinogenic compounds, aluminum — nitrilotriacetate complex (A1—NTA), n...
Gespeichert in:
| Veröffentlicht in: | Carcinogenesis (New York) 1990-02, Vol.11 (2), p.345-347 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | A significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) was observed in the kidney DNA of rats given a renal carcinogen, the ferric complex of nitrilotriacetate (Fe—NTA) by single i.p. injection. By contrast, non- or weakly carcinogenic compounds, aluminum — nitrilotriacetate complex (A1—NTA), non-complexed NTA (Na2NTA) and ferric chloride had no effect on 8-OH-dG production in the kidney DNA. These results suggest the involvement of active oxygen radicals in Fe—NTA carcinogenesis. |
|---|---|
| ISSN: | 0143-3334 1460-2180 |
| DOI: | 10.1093/carcin/11.2.345 |