Pretreatment with alfentanil reduces pain caused by propofol

We have compared two groups (n= 22) of unpre-medicated patients to determine if the pain caused by injection of propofoi could be modified by alfentanil. In group I, alfentanil 1 mg was given as a bolus i. v. injection 15s before administration of propofoi i. v., while group II received saline. Prop...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1994-03, Vol.72 (3), p.342-344
Hauptverfasser:	FLETCHER, J.E., SEAVELL, C.R., BOWEN, D.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alfentanil - therapeutic use Anaesthetics Anaesthetics, i. v.: propofoi Analgesics Analgesics, opioid: alfentanil Anesthetics. Neuromuscular blocking agents Biological and medical sciences Double-Blind Method Humans i. v.: propofoi Injections, Intravenous - adverse effects Medical sciences Middle Aged Neuropharmacology opioid: alfentanil Pain - prevention & control Pain Measurement Pain: injection Pharmacology. Drug treatments Preanesthetic Medication Propofol - adverse effects Time Factors
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Zusammenfassung:	We have compared two groups (n= 22) of unpre-medicated patients to determine if the pain caused by injection of propofoi could be modified by alfentanil. In group I, alfentanil 1 mg was given as a bolus i. v. injection 15s before administration of propofoi i. v., while group II received saline. Propofoi was given in 20-mg increments every 4 s. All injections were given through the same i. v. cannula on the dorsum of one hand. We found that alfentanil pretreatment reduced pain on injection of propofoi (P = 0.001). (Br. J. Anaesth. 1994; 72: 342–344)
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/72.3.342