EFFECT OF PROLONGED SEDATION WITH PROPOFOL ON SERUM TRIGLYCERIDE AND CHOLESTEROL CONCENTRATIONS

We compared changes in serum lipid concentrations in ICU patients receiving a 3-day continuous infusion of propofol with those in patients receiving conventional sedation. No adverse effects were observed and the serum lipid concentrations were not significantly influenced by propofol. It is conclud...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1989-04, Vol.62 (4), p.393-396
Hauptverfasser:	GOTTARDIS, M., KHÜNL-BRADY, K.S., KOLLER, W., SIGL, G., HACKL, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics. Neuromuscular blocking agents Biological and medical sciences Cholesterol - blood Cholesterol, HDL - blood Critical Care Female Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - pharmacology Infusions, Intravenous Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Phenols - administration & dosage Phenols - adverse effects Phenols - pharmacology Propofol Time Factors Triglycerides - blood
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Zusammenfassung:	We compared changes in serum lipid concentrations in ICU patients receiving a 3-day continuous infusion of propofol with those in patients receiving conventional sedation. No adverse effects were observed and the serum lipid concentrations were not significantly influenced by propofol. It is concluded that propofol might be a suitable agent for long-term sedation in the ICU, although serum lipid concentrations should be monitored throughout its administration.
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/62.4.393