COMPARISON OF THE EFFECTS OF ORG NC45 AND PANCURONIUM BROMIDE ON HEART RATE AND ARTERIAL PRESSURE IN ANAESTHETIZED MAN

The effects of Org NC 45 and pancuronium bromide on heart rate and arterial pressure were studied in anaesthetized man A bolus of either Org NC450.12mg kg−1 or pancuronium 0.1 mg kg−1 was administered to lightly anaesthetized unstunulated subjects. Following Org NC 45 heart rate decreased in the majority of subjects (mean and SEM 3.78 ± 1.36), whereas after pancuronium heart rate was increased (mean and SEM 11.91 ± 1 9). The changes in mean arterial pressure observed were minimal The effect of endotracheal intubation on mean arterial pressure was then studied. Increase of mean arterial pressure was observed in all subjects. The increase was more marked in those patients who had received pancuronium and was significantly higher than m those patients who had received Org NC45 (P