CHANGES IN CANINE MYOCARDIAL BLOOD FLOW AND OXYGEN CONSUMPTION IN RESPONSE TO HALOTHANE

The effect of 0.5, 1 and 1.5 per cent inspired halothane concentrations on myocardial blood flow has been studied using a xenon-133 clearance technique in 12 dogs anaesthetized with pentobarbitone 30 mg/kg body weight. Halothane was found to reduce cardiac output, mean systemic arterial pressure, my...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of anaesthesia : BJA 1974-11, Vol.46 (11), p.821-826
Hauptverfasser:	SMITH, G., MCMILLAN, J.C., VANCE, J.P., BROWN, D.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Coronary Circulation - drug effects Dogs Halothane - pharmacology Heart - drug effects Hemodynamics - drug effects Myocardium - metabolism Oxygen Consumption - drug effects Time Factors Vascular Resistance - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The effect of 0.5, 1 and 1.5 per cent inspired halothane concentrations on myocardial blood flow has been studied using a xenon-133 clearance technique in 12 dogs anaesthetized with pentobarbitone 30 mg/kg body weight. Halothane was found to reduce cardiac output, mean systemic arterial pressure, myocardial blood flow and oxygen consumption in proportion to its inspired concentration. With the higher concentrations of halothane, there was a small increase in myocardial vascular resistance associated with a small, significant reduction in coronary sinus Po2 and oxygen content.
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/46.11.821