A - 114 Exploring Alzheimer’s Disease: the Interplay of Depression, Substance Use, and Neurocognition

Abstract Objective Depression and substance use (SU) can significantly impact one’s neurocognition and are potential risk factors for Alzheimer’s Disease (ad). The project aimed to explore whether a history of depression and/or SU could predict baseline performance on neuropsychological assessment among individuals with and without ad. Method Data from the National Alzheimer’s Coordinating Center (NACC) was analyzed. N = 9114 participants (41.5% Male, 58.5% Female; 56.7% Normal Cognition, 43.2% ad) at their first visit were selected. A series of linear regression models, separated by presence of ad diagnosis, were run to determine if a history of depression, and/or SU, age, race, sex, education level, and APOE status would predict performance on selected neuropsychological assessments measuring facets of executive functioning (EF) (Trail Making, Digit Span, and Wechsler Adult Intelligence Scale (WAIS)). Results Depression was a significant predictor of performance on the WAIS in the normal cognition (β = −0.12,p