A-050 Association between Executive Functioning Performance and Resting State Connectivity in Pediatric Survivors of Acute Lymphoblastic Leukemia

Abstract Objective To explore differences between executive functioning (EF) and resting-state functional connectivity (rs-FC) of the executive control network (ECN) in survivors of acute lymphoblastic leukemia (ALL) compared to healthy controls. Method ALL participants (age 9-18) from Children’s of Alabama Hospital were ≥ 5 years post-diagnosis treated with chemotherapy only. Eleven ALL survivors and twelve controls were administered the Delis-Kaplan Executive Function Scale (D-KEFS) and Behavior Rating Inventory of Executive Function (BRIEF-2) self- and parent report. Using seed-to-voxel rs-FC analyses, we examined ECN regions (e.g., medial and dorsolateral prefrontal cortex [MPFC; dlPFC]). Within group multiple regression analyses were conducted to correlate EF scores to rs-FC z-scores. Results No significant differences were found on EF scores between ALL and control groups. rs-FC analyses indicated ECN hyperconnectivity in ALL survivors compared to controls (p