Ipilimumab-related hypophysitis may precede severe CNS immune attack

Reintroduction of ipilimumab after recovery or hormonal substitution for hypophysitis should be carefully done especially in the presence of minor neurological symptoms or signs (such as tinnitus) which should be considered as red flags for subsequent severe central nervous immune attack.

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Veröffentlicht in:Annals of oncology 2016-10, Vol.27 (10), p.1975-1976
Hauptverfasser: Köessler, T., Olivier, T., Fertani, S., Marinari, E., Dutoit, V., Dietrich, P.-Y.
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container_end_page 1976
container_issue 10
container_start_page 1975
container_title Annals of oncology
container_volume 27
creator Köessler, T.
Olivier, T.
Fertani, S.
Marinari, E.
Dutoit, V.
Dietrich, P.-Y.
description Reintroduction of ipilimumab after recovery or hormonal substitution for hypophysitis should be carefully done especially in the presence of minor neurological symptoms or signs (such as tinnitus) which should be considered as red flags for subsequent severe central nervous immune attack.
doi_str_mv 10.1093/annonc/mdw255
format Article
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subjects Antineoplastic Agents, Immunological - adverse effects
Female
Humans
Hypophysitis - chemically induced
Hypophysitis - diagnosis
Hypophysitis - immunology
Ipilimumab - adverse effects
Middle Aged
Severity of Illness Index
title Ipilimumab-related hypophysitis may precede severe CNS immune attack
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