Ipilimumab-related hypophysitis may precede severe CNS immune attack

Ipilimumab-related hypophysitis may precede severe CNS immune attack

Reintroduction of ipilimumab after recovery or hormonal substitution for hypophysitis should be carefully done especially in the presence of minor neurological symptoms or signs (such as tinnitus) which should be considered as red flags for subsequent severe central nervous immune attack.

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Bibliographische Detailangaben
Veröffentlicht in:Annals of oncology 2016-10, Vol.27 (10), p.1975-1976
Hauptverfasser: Köessler, T., Olivier, T., Fertani, S., Marinari, E., Dutoit, V., Dietrich, P.-Y.
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents, Immunological - adverse effects
Female
Humans
Hypophysitis - chemically induced
Hypophysitis - diagnosis
Hypophysitis - immunology
Ipilimumab - adverse effects
Middle Aged
Severity of Illness Index
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Zusammenfassung:Reintroduction of ipilimumab after recovery or hormonal substitution for hypophysitis should be carefully done especially in the presence of minor neurological symptoms or signs (such as tinnitus) which should be considered as red flags for subsequent severe central nervous immune attack.
ISSN:0923-7534
1569-8041
DOI:10.1093/annonc/mdw255