Paraventricular Nucleus Lesions Attenuate the Development of Hypertension in DOC A/Salt-Treated Rats

Paraventricular Nucleus Lesions Attenuate the Development of Hypertension in DOC A/Salt-Treated Rats

To determine whether paraventricular nucleus (PVN) can play a role in the hypertension in DOCA/salt-treated rats, DOCA/salt hypertension was produced in PVN lesions and sham-operated rats. In lesioned rats, the development of hypertension was significantly attenuated (day 7 : 132 ± 3 ν 157 ± 5 mm Hg...

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Veröffentlicht in:American journal of hypertension 1989-08, Vol.2 (8), p.625-630
Hauptverfasser: Nakata, Tetsuo, Takeda, Kazuo, Itho, Hiroshi, Hirata, Masahiro, Kawasaki, Shingo, Hayashi, Junko, Oguro, Minako, Sasaki, Susrimu, Nakagawa, Masao
Format: Artikel
Sprache:eng
Schlagworte:
DOCA/salt hypertensive rats
Paraventricular nucleus
sympathetic nervous system
vasopressin
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Zusammenfassung:To determine whether paraventricular nucleus (PVN) can play a role in the hypertension in DOCA/salt-treated rats, DOCA/salt hypertension was produced in PVN lesions and sham-operated rats. In lesioned rats, the development of hypertension was significantly attenuated (day 7 : 132 ± 3 ν 157 ± 5 mm Hg, P < 0.01; day 14 : 132 ± 3 ν 157 ± 5 mm Hg, P < 0 . 01 ; day 21: 189 ± 2 ν 224 ± 6 mm Hg, P
ISSN:0895-7061
1941-7225
DOI:10.1093/ajh/2.8.625