Quantitative one-stage assays for factors V and X

The relative sensitivities of the prothrombin time, Russell's viper venom time and activated partial thromboplastin time were determined in one-stage quantitative assays for factor V and factor X. Sensitivity was defined as the slope of the reference curve. The prothrombin time was the most sen...

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Veröffentlicht in:American journal of clinical pathology 1975-12, Vol.64 (6), p.817-819
Hauptverfasser: Babson, A L, Flanagan, M L
Format: Artikel
Sprache:eng
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Zusammenfassung:The relative sensitivities of the prothrombin time, Russell's viper venom time and activated partial thromboplastin time were determined in one-stage quantitative assays for factor V and factor X. Sensitivity was defined as the slope of the reference curve. The prothrombin time was the most sensitive test for factor X and the least sensitive for factor V. The Russell's viper venom time was the most sensitive test for factor V and least sensitive for factor X. The activated partial thromboplastin time approximated the sensitivity of Russell's viper venom for factor V and had intermediate sensitivity for factor X. The data indicate that factor V is best quantitated by the Russell's viper venom time and factor X by the prothrombin time, exactly the opposite of what is customarily done.
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/64.6.817