Effects of fish-oil supplementation on myocardial fatty acids in humans

BACKGROUND: Increased fish or fish-oil consumption is associated with reduced risk of cardiac mortality, especially sudden death. This benefit putatively arises from the incorporation of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cardiomyocyte phos...

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Veröffentlicht in:	The American journal of clinical nutrition 2007-05, Vol.85 (5), p.1222-1228
Hauptverfasser:	Metcalf, Robert G, James, Michael J, Gibson, Robert A, Edwards, James RM, Stubberfield, John, Stuklis, Robert, Roberts-Thomson, Kurt, Young, Glenn D, Cleland, Leslie G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged arachidonic acid Biological and medical sciences Cardiopulmonary Bypass cardiovascular diseases Cardiovascular Diseases - metabolism Cardiovascular Diseases - mortality Cardiovascular Diseases - surgery cell membranes dietary fat Dietary Supplements docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - pharmacokinetics dosage eicosapentaenoic acid Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - pharmacokinetics fatty acid composition Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-3 - pharmacokinetics Feeding. Feeding behavior Female fish oils Fish Oils - administration & dosage Fish Oils - chemistry Fundamental and applied biological sciences. Psychology Humans Linseed Oil - administration & dosage Linseed Oil - chemistry Male Membrane Lipids - chemistry Membrane Lipids - metabolism Middle Aged mortality myocardium Myocardium - cytology Myocardium - metabolism Olive Oil patients phospholipids Phospholipids - chemistry Phospholipids - metabolism Plant Oils - administration & dosage Plant Oils - chemistry risk assessment Risk Factors risk reduction temporal variation Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Beschreibung
Zusammenfassung:	BACKGROUND: Increased fish or fish-oil consumption is associated with reduced risk of cardiac mortality, especially sudden death. This benefit putatively arises from the incorporation of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cardiomyocyte phospholipids. OBJECTIVE: The study examined the kinetics of incorporation of n-3 fatty acids into human myocardial membrane phospholipids during supplementation with fish oil and α-linolenic acid-rich flaxseed oil. DESIGN: Patients with low self-reported fish intake (
ISSN:	0002-9165 1938-3207
DOI:	10.1093/ajcn/85.5.1222