Wnt/Ca^2＋ signaling pathway： a brief overview

The non-canonical Wnt/Ca^2＋ signaling cascade is less characterized than their canonical counterpart, the Wnt/β-catenin pathway. The non-canonical Wnt signaling path- ways are diverse, defined as planer cell polarity pathway, Writ-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Writ/Ca^2＋ signaling pathway was deci- phered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca^2＋ pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Writ/Ca^2＋ signaling pathway.