Corneal endothelial deposits associated with rifabutin use

The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin. Case series consisting of 3 patients treated with rifabutin were retrospectively studied. Two of the patients were infected with human immunodeficiency virus. A corneal and external disease specialist performed a complete ophthalmologic exam and obtained medical histories of the patients. All cases developed corneal endothelial deposits after previous use of rifabutin. The deposits were bilateral, yellow-white colored, stellate, and mainly peripheral. In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.