Fenretinide does not block visual pigment formation in the rat

Abnormal retinal function has been reported in patients receiving the synthetic retinoid fenretinide. In this study, the vitamin A deprived rat was used as a model to test the possibility that fenretinide is interfering with the vitamin A transport system and/or blocking the normal uptake of 11-cis...

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Veröffentlicht in:	Journal of ocular pharmacology 1988, Vol.4 (3), p.253-257
Hauptverfasser:	CROUCH, R. K, GOLETZ, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cattle Drug toxicity and drugs side effects treatment Eye Proteins - metabolism Fenretinide Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Photoreceptor Cells - metabolism Rats Rats, Inbred Strains Retinal Pigments - biosynthesis Retinaldehyde - metabolism Rhodopsin - biosynthesis Rod Opsins Tretinoin - analogs & derivatives Tretinoin - pharmacology Vitamin A - metabolism
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Beschreibung
Zusammenfassung:	Abnormal retinal function has been reported in patients receiving the synthetic retinoid fenretinide. In this study, the vitamin A deprived rat was used as a model to test the possibility that fenretinide is interfering with the vitamin A transport system and/or blocking the normal uptake of 11-cis retinal into the visual pigment. Assessing retinal function by electroretinogram measurements and visual pigment formation by competition studies, our data demonstrate normal uptake of vitamin A and normal visual pigment formation in the rat after treatment with the drug.
ISSN:	8756-3320 1080-7683 1557-7732
DOI:	10.1089/jop.1988.4.253